发明名称 |
METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS |
摘要 |
<p>The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonist to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L- DOPA therapy in the treatment of Parkinson~s disease. The present invention further provides methods and compositions for treating Parkinson~s disease patients with sub-clinically effective doses of L-DOPA by combining LDOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson~s disease by co- administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson~s disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.</p> |
申请公布号 |
CA2473864(A1) |
申请公布日期 |
2003.08.07 |
申请号 |
CA20032473864 |
申请日期 |
2003.01.28 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
KASE, HIROSHI;MORI, AKIHISA;KARASAWA, AKIRA;OHSAWA, YUTAKA;WAKI, YUTAKA;KUWANA, YOSHIHISA |
分类号 |
C07D473/06;A61K31/522;A61K45/00;A61P25/14;A61P25/16;(IPC1-7):A61K31/522 |
主分类号 |
C07D473/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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