发明名称 |
STABLE ORAL COMPOSITIONS COMPRISING CASEIN PHOSPHOPEPTIDE COMPLEXES AND FLUORIDE |
摘要 |
The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex ("PP-ACP"); a safe and effective amount of a fluoride ion source; a safe and effective amount of a phosphate buffer; a pharmaceutically-acceptable topical, oral carrier; wherein the pH of the final composition is greater than 8 to about 12 and the composition has improved fluoride stability. This invention further relates to a method of maintaining the fluoride levels in an oral care composition comprising a safe and effective amount of PP-ACP, a safe and effective amount of a fluoride ion source, and a pharmaceutically-acceptable topical, oral carrier, by adjusting the pH of the composition to greater than 8 to about 12 and by adding, to the composition, a safe and effective amount of a phosphate buffer. |
申请公布号 |
WO03059303(A2) |
申请公布日期 |
2003.07.24 |
申请号 |
WO2002US39599 |
申请日期 |
2002.12.11 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
DIXON, CLOYD, JR.;KAMINSKI, MICHAEL, ANTHONY;HUGHES, TIMOTHY, JOHN |
分类号 |
A61K8/21;A61K8/24;A61K8/64;A61Q11/00 |
主分类号 |
A61K8/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|