| 发明名称 |
NOVEL STREPTOGRAMINS, METHOD FOR THEIR PREPARING, NUCLEOTIDE SEQUENCES, POLYPEPTIDES AND PHARMACEUTICAL COMPOSITION |
| 摘要 |
FIELD: biotechnology, antibiotics, pharmacy. SUBSTANCE: invention relates to novel streptogramins of the formula (I) and to method for preparing streptogramins by mutasynthesis using a mutated microorganism for alternation of biosynthesis of at least a single precursor of streptogramins. Invention describes also nucleotide sequences and polypeptides taking part in biosynthesis of these precursors. Invention describes also pharmaceutical composition based on the claimed compounds and eliciting an antibacterial activity. EFFECT: improved preparing method, valuable medicinal properties of compounds. 40 cl, 13 dwg, 5 tbl |
| 申请公布号 |
RU2205183(C2) |
申请公布日期 |
2003.05.27 |
| 申请号 |
RU19970101899 |
申请日期 |
1995.07.04 |
| 申请人 |
RON-PULENK RORE S.A. |
发明人 |
BLAN VERONIK;TIBO DENI;BAMA-ZHAK NATALI;BLANSH FRANSIS;KRUZE ZHOEHL';BAR'ER ZHAN-KLOD;DEBJUSSH LORAN;FAMESHON ALAN;PARI ZHAN-MARK;DJUTRJUK-ROSSE ZHILL' |
| 分类号 |
C12N15/09;A61K31/4745;A61K38/00;C07C229/36;C07C229/42;C07C233/15;C07C233/25;C07C323/63;C07D295/02;C07D295/155;C07D498/14;C07K7/06;C07K7/64;C12N1/21;C12N9/00;C12N15/00;C12N15/52;C12N15/76;C12P17/10;C12P21/04;C12R1/465 |
主分类号 |
C12N15/09 |
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