发明名称 |
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair |
摘要 |
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
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申请公布号 |
US2002115647(A1) |
申请公布日期 |
2002.08.22 |
申请号 |
US20020125106 |
申请日期 |
2002.04.18 |
申请人 |
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发明人 |
HALVORSEN YUAN-DI C.;WILKISON WILLIAM O.;GIMBLE JEFFREY MARTIN |
分类号 |
A61K35/12;C12N5/02;C12N5/077;(IPC1-7):A61K31/56;C12N5/08 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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