发明名称 |
MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO |
摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from <i>hedgehog</i> gain-of-function, <i>ptc</i> loss-of-function or <i>smoothened</i> gain-of-function comprising contacting the cell with a <i>hedgehog</i> antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal <i>ptc</i> pathway or antagonize <i>smoothened</i> or <i>hedgehog</i> activity.
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申请公布号 |
WO0126644(A3) |
申请公布日期 |
2002.04.18 |
申请号 |
WO2000US28579 |
申请日期 |
2000.10.13 |
申请人 |
CURIS, INC. |
发明人 |
BAXTER, ANTHONY, DAVID;BOYD, EDWARD, ANDREW;GUICHERIT, OIVIN, M.;PRICE, STEPHEN;RUBIN, LEE |
分类号 |
C07D403/14;A61K31/40;A61K31/4025;A61K31/496;A61P1/16;A61P11/00;A61P15/00;A61P17/00;A61P17/14;A61P19/08;A61P21/00;A61P35/00;A61P43/00;C07D207/14;C07D405/06;C07D409/06;(IPC1-7):A61K31/40;A61K31/495 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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