发明名称 |
COMPUESTOS DERIVADOS DE BENCIMIDAZOL; PROCEDIMIENTO DE PREPARACION; COMPOSICIONES FARMACEUTICAS; Y USO PARA EL TRATAMIENTO Y/O PROFILAXIS DE ENFERMEDADES QUE SE MODULAN CON AGONISTAS DEL FXR, TAL COMO DISLIPIDEMIAS, DIABETES, CANCER, OSTEOPOROSIS Y E |
摘要 |
The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia. |
申请公布号 |
CL2007001869(A1) |
申请公布日期 |
2008.02.08 |
申请号 |
CL20070001869 |
申请日期 |
2007.06.26 |
申请人 |
F. HOFFMANN-LA ROCHE AG. |
发明人 |
GREGORY MARTIN BENSON,KONRAD BLEICHER,ALEXANDER CHUCOLOWSKI,HENRIETTA DEHMLOW,UWE GRETHER,BERND KUHN,RAINER E.MARTIN,ERI |
分类号 |
A61K31/4184;A61P3/06;A61P3/10;A61P19/10;A61P25/16;A61P35/00;C07D235/18;C07D403/04 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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