4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF

摘要

The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula (V). In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR<1>R<2>, or (N<+>R<1>R<2>R<3>)X<->, R<1> and R<2> are independently a C1-C6 alkyl, or R<1> and R<2> together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N<+>R<1>R<2>R<3>)X<->, R<1> and R<2> together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R<3> is hydroge, a C1-C12 alkyl, or, when R<1> and R<2> together with the nitrogen form a heterocyclic aromatic ring, R<3> is a double bond within the heterocyclic aromatic ring; X is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.