发明名称 |
Preparation of diagnostic agents |
摘要 |
<p>Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules. Suitable wall-forming materials include proteins such as albumin and gelatin. The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.</p> |
申请公布号 |
EP0972526(A2) |
申请公布日期 |
2000.01.19 |
申请号 |
EP19990203198 |
申请日期 |
1992.04.10 |
申请人 |
ELAN DRUG DELIVERY LIMITED |
发明人 |
SUTTON, ANDREW DEREK;JOHNSON, RICHARD ALAN;SENIOR, PETER JAMES;HEATH, DAVID |
分类号 |
A61K49/14;A61B8/14;A61K9/16;A61K9/50;A61K49/00;A61K49/22;B01J;B01J13/02;B01J13/04;B01J13/14;(IPC1-7):A61K49/00 |
主分类号 |
A61K49/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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