发明名称 |
HETEROARYL DIAZACYCLOALKANES AS CHOLINERGIC LIGANDS AT NICOTINIC ACETYLCHOLINE RECEPTORS |
摘要 |
The present invention discloses compounds of formula (I) any of its enantiomers or any mixture thereof, isotopes thereof or a pharmaceutically acceptable salt thereof; wherein n is 1, 2 or 3; m is 0, 1 or 2; R represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; and R<1> represents aminophenyl; nitrophenyl; hydroxyphenyl, alkoxyphenyl; a monocyclic 5 to 6 membered heterocyclic group which may be substituted one or more times with substituents or R<1> represents a bicyclic heterocyclic group, composed of 5 to 6 membered monocyclic heterocyclic group fused to a benzene ring, and which may be substituted one or more times with substituents. The compounds of the invention are useful as nicotinic ACh receptor ligands. |
申请公布号 |
WO9921834(A1) |
申请公布日期 |
1999.05.06 |
申请号 |
WO1998DK00465 |
申请日期 |
1998.10.27 |
申请人 |
NEUROSEARCH A/S;PETERS, DAN;OLSEN, GUNNAR, M.;NIELSEN, SIMON, FELDBAEK;NIELSEN, ELSEBET, OESTERGAARD |
发明人 |
PETERS, DAN;OLSEN, GUNNAR, M.;NIELSEN, SIMON, FELDBAEK;NIELSEN, ELSEBET, OESTERGAARD |
分类号 |
C07D217/22;A61K31/4406;A61K31/4418;A61K31/4425;A61K31/4427;A61K31/443;A61K31/4433;A61K31/495;A61K31/496;A61K31/497;A61K31/501;A61K31/551;A61P1/12;A61P9/10;A61P11/06;A61P21/02;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P25/30;A61P29/00;C07D213/22;C07D213/74;C07D215/38;C07D243/08;C07D401/04;C07D401/14;C07D403/04;C07D405/04;C07D409/04;C07D409/14;C07D417/04;C07D417/14 |
主分类号 |
C07D217/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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