ARGININANTAGONISTEN ZUR HEMMUNG DES SYSTEMISCHEN BLUTDRUCKES IN ZUSAMMENHANG MIT STICKOXIDBILDUNG ODER ENDOTHELIAL DERIVED RELAXING FAKTOR
摘要
A method for prophylaxis or treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide formation from arginine. Preferably N<G>-substituted arginine or an N<G>,N<G>-disubstituted arginine (having at least one hydrogen on a terminal guanidino amino group replaced by another atomic species) is administered to an animal possibly developing or already having such induced systemic hypotension. The arginine derivatives are preferably of the L configuration and include pharmaceutically acceptable addition salts. Prophylaxis or treatment of systemic hypotension in a patient which has been induced by chemotherapeutic treatment with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, i.e., septic shock may also be accomplished by treatment with the arginine derivatives.
申请公布号
AT175871(T)
申请公布日期
1999.02.15
申请号
AT19900913926T
申请日期
1990.09.13
申请人
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;CORNELL RESEARCH FOUNDATION, INC.
发明人
KILBOURNE, ROBERT, G.;GROSS, STEVEN, S.;LEVI, ROBERTO;GRIFFITH, OWEN, W.;LODATO, ROBERT