发明名称 |
Method for loading lipsomes with ionizable phosphorylated hydrophobic compounds, pharmaceutical preparations and a method for administering the preparations |
摘要 |
A method of entrapping ionizable compounds, preferably phosphorylated hydrophobic compounds, into liposomes having transmembrane gradients is disclosed. The procedures involve forming liposomes in an acidic medium or a basic medium, adding to the acidic medium a cationic compound or to the basic medium an anionic compound and then adding a base to the cationic-containing medium or an acid to the anionic-containing medium, thereby inducing the ionizable compound into the liposomes' internal aqueous phase. The compound-entrapped liposomes prepared in accordance with the disclosed methods may be used as pharmaceutical preparations. Methods of administering such pharmaceutical preparations are also disclosed.
|
申请公布号 |
US5827532(A) |
申请公布日期 |
1998.10.27 |
申请号 |
US19970791557 |
申请日期 |
1997.01.31 |
申请人 |
THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MEHLHORN, ROLF JOACHIM |
分类号 |
A61K9/127;(IPC1-7):A61K9/133 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|