| 摘要 |
PROBLEM TO BE SOLVED: To obtain a diagnostic agent for diabetic symptomless kidney obstacle containing parathyroid hormones. SOLUTION: This diagnosis agent processes an ascending function of serum calcium and includes 10-400 units, especially 50-100 units, of parathyroid hormones or their salts comprising peptides or their salts bearing molecular weights of ca. 4,000-10,000 as an active ingredient. Preferably, a human- parathyroid hormone (1-34) bearing 34 amino acid sequence of the molecular weight of ca. 4,400 is illustrated and thyriparatide acetate is exemplified as the salt. This diagnostic agent is formulated in forms of injection, rectum absorbent, cutanous absorbent, oral administrating agent, etc. This agent diagnoses a kidney function having symptomless kidney obstacle, which is not yet diagnosed to be renal diabetes through it is diabetes, due to the rate of excretion below 15μm/min., and is useful for prevention against attack and advance. The diagnosis is carried out by detecting a trace of albumin in urine by NAG increasing reaction in urine after administrating parathyroid hormones.
|
