VECTORS AND PROKARYOTES WHICH AUTOCATALYTICALLY DELETE ANTIBIOTIC RESISTANCE
摘要
A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.
申请公布号
WO9633269(A1)
申请公布日期
1996.10.24
申请号
WO1996US05250
申请日期
1996.04.16
申请人
MEDIMMUNE, INC.;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNI;UNIVERSITY OF PITTSBURGH
发明人
HAUN, SHIRLEY, L.;STOVER, CHARLES, K.;HATFULL, GRAHAM;HANSON, MARK, S.;JACOBS, WILLIAM, R.