PROCESS FOR THE PREPARATION OF (20R)-16 ALPHA,17 ALPHA -BUTYLIDENEDIOXY-6 ALPHA,9 ALPHA-DIFLUORO-11 BETA-HYDROXY 17 BETA-(METHYLTHIO) ANDROST-4-3-ONE

摘要

A process is described for the preparation of (20R)-16 alpha ,17 alpha -butylidenedioxy-6 alpha ,9 alpha -difluoro-11 beta -hydroxy-17 beta -(methylthio)androst-4-en-3-one comprising a six step synthesis from a compound of formula (I). (20R)-16 alpha ,17 alpha -Butylidenedioxy-6 alpha ,9 alpha -difluoro-11 beta -hydroxy-17 beta -(methylthio) androst-4-en-3-one is a pharmacologically active steroid which possesses anti-inflammatory, immunosuppressive and anti-allergic activity.