Methods and compounds active at metabotropic glutamate receptors useful for treatment of neurological disorders and diseases

摘要

The present invention concerns compounds and methods for modulating metabotropic glutamate receptor activity. The compounds are targeted to a binding site on the metabotropic glutamate receptor which appears to be distinct from the glutamate receptor binding site. The preferred use of the compounds and methods of the present invention is to modulate metabotropic glutamate receptor activity and thereby aid in the treatment of neurological diseases or disorders. The compounds can also be used to produce other effects such as an analgesic effect, cognition-enhancement effect, and a muscle-relaxant effect.