CONSTRUCCIONES DE ANTIGENOS DE ANTIGENOS DEL COMPLEJO DE HISTOCOMPATIBILIDAD PRINCIPAL DE LA CLASE I CON MOLECULAS DE VEHICULO ESPECIFICAS, SU PREPARACION Y EMPLEO.

摘要

Antigen constructs which result from linkage of major histocompatibility complex (MHC) Class I antigens to specific carrier molecules are described. The linkage takes place at the N or C terminus by covalent bonding or, in the case of non-covalent bonding, e.g. via avidin-biotin bridging. The specific carrier molecules bind selectively to target cells and are preferably monoclonal antibodies. Genetic engineering processes for the production of such constructs are indicated. Antigen constructs according to the invention are used for damaging or eliminating target cells.