| 摘要 |
Rhizoxin and rhizoxin-2-ene derivatives of formula (I): <IMG> (I) ¢in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R1 and R2, where R1 and R2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono,alkylphosphono or dialkylphosphono! have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.
|
