PROCESS OF MAKING SPIROCYCLES AND ANALOGS THEREOF

摘要

The present invention is directed to a process of making spirocycles of general structural formula (I), where R1 is selected from the group consisting of CO-CO1-3 alkyl, cyano, carboxy, carboxy C1-6 alkyl ester, carboxamide, C1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, C1-6 methanesulfonamide and halogen; R2 is selected from the group consisting of keto or alcohol, R3 is cyano, resulting in compounds which are Class III antiarrhythmic.