| 摘要 |
Pharmaceutical compositions comprising a therapeutic agent, an effective stabilizing amount of carboxy-containing polymer and cyclodextrin, in an aqueous medium, wherein said cyclodextrin is selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of alpha , beta and gamma -cyclodextrin, modified or unmodified; and methods for stabilizing and solubilizing a therapeutic agent in a pharmaceutial composition, comprising combining said therapeutic agent in an aqueous medium with an effective stabilizing amount of carboxy-containing polymer and an amount of cyclodextrin sufficient to at least partially solubilize said therapeutic agent, said cyclodextrin being selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of alpha , beta and gamma -cyclodextrin, modified or unmodified. |
