2-(Tetranol-5-yl)-(1,1'-biphenyl)derivatives, their preparation and use as intermediates.

摘要

Compounds corresponding to the formula (I) <IMAGE> in which X represents either a dibromomethyl group, or a formyl group, or a (C1-4)alkyl group, or a group CH(OR5)2, or a group CH(OH)OR5, R5 being a hydrogen atom or a (C1-3)alkyl group which can optionally form, in the case of CH(OR5)2, a 1,3-dioxolane or 1,3-dioxane ring and Y represents either a hydrogen atom, or a 1,1-dimethylethyl group, or a triphenylmethyl group, or a trimethylstannyl group, or a tributylstannyl group, or a (1,1-dimethylethyl)dimethylsilyl group, or a (1,1-dimethylethyl)diphenylsilyl group, or a 2-cyanoethyl group, or a group CH2OR6 where R6 is a methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxy-carbonyl group, Y being in position 1 or 2 of the tetrazole ring. Use as intermediates in the synthesis of compounds having therapeutic activity.