| 摘要 |
<p>Compounds of general formula (I), pharmaceutically acceptable salts thereof or stereoisomeric forms thereof, wherein 1 = 1, 2 or 3, n is an integer from 1-6, where X is independently selected from H, =O, =CH2, aryl, COR, OR, COOR or X = -(CR1R2)r-R3 where r is an integer from 1-10 and where r > 1, optionally at least 1 carbon atom can be replaced by O, S or N; R1, R2 and R3 are independently selected from H; alkyl, alkenyl, alkynyl, aryl, each optionally substituted by one or more substituents selected from alkyl, alkenyl, alkynyl, aryl, halogen, OR, CF3, NO2, COOR, NRR', SR, COR, CONRR', SO3R, SO2NRR', SR, SOR, and SO2R, where R and R' are independently selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl or optionally substituted arylalkyl wherein the optional substituents are as defined above. These compounds are structurally similar to the naturally occurring biologically active compound qinghaosu (Artemisinin) and some compounds have activities superior to that of qinghaosu.</p> |
