发明名称 |
TRI- AND TETRA-VALENT MONOSPECIFIC ANTIGEN-BINDING PROTEINS |
摘要 |
The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer. |
申请公布号 |
WO9222583(A2) |
申请公布日期 |
1992.12.23 |
申请号 |
WO1992GB01047 |
申请日期 |
1992.06.11 |
申请人 |
CELLTECH LIMITED |
发明人 |
KING, DAVID, JOHN;TURNER, ALISON;BEELEY, NIGEL, ROBERT, ARNOLD;MILLICAN, THOMAS, ANDREW |
分类号 |
A61K38/00;A61K39/395;A61K49/00;A61K51/10;A61P35/00;C07C235/12;C07C237/12;C07D207/44;C07D207/452;C07D403/12;C07K;C07K1/00;C07K5/02;C07K14/00;C07K16/00;C07K16/18;C07K16/30;C07K19/00;C12P21/04;G01N33/531;G01N33/566;G01N33/574;G01N33/577 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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