Novel thiazole derivatives.

摘要

A novel thiazole derivative of formula [1] or a pharmaceutically acceptable salt thereof: <CHEM> wherein A is a singe bond, straight-chained or branched-chained lower alkylene or straight-chained or branched lower alkenylene, B is a single bond or -CO-; R<1> is carboxy or -CON(R<7>)OR<8> (R<7> and R<8> are the same or different and each is hydrogen or lower alkyl); R<2> is lower alkyl; R<3> and R<4> are the same or different and each is hydrogen, lower alkyl or lower alkoxycarbonyl; R<5> is hydrogen or halogen; and R<6> is hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, thiol, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, substituted amino, cyano, carboxy or acyl. The compounds of the present invention are useful as therapeutic or preventive drugs for autoimmune diseases and inflammatory diseases.