摘要 |
<p>Compounds of formula (I): <CHEM> [in which: R<1> is heterocyclic group having 5 or 6 ring atoms, or -NR<7>R<8>, where R<7> is alkyl and R<8> is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R<2> is optionally substituted phenyl or naphthyl; R<3> is thiazolyl; R<4> is cyclohexyl or isopropyl; R<5> is alkyl; and R<6> is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.</p> |
申请人 |
SANKYO COMPANY LIMITED |
发明人 |
MORISAWA, YASUHIRO, C/O SANKYO COMPANY LTD.;KATAOKA, MITSURU, C/O SANKYO COMPANY LTD.;YABE, YUICHIRO, C/O SANKYO COMPANY LTD.;KOIKE, HIROYUKI, C/O SANKYO COMPANY LTD.;TAKAHAGI, HIDEKUNI, C/O SANKYO COMPANY LTD.;IIJIMA, YASUTERU, C/O SANKYO COMPANY LTD.;KOKUBU, TATSUO;HIWADA, KUNIO |