GRAFTED CHROMATOGRAPHIC FILLER AND METHOD FOR ANALYZING ENANTIOMER MIXTURE USING SAME

摘要

PCT No. PCT/JP83/00145 Sec. 371 Date Jan. 18, 1984 Sec. 102(e) Date Jan. 18, 1984 PCT Filed May 18, 1983 PCT Pub. No. WO83/04103 PCT Pub. Date Nov. 24, 1983.A packing material for chromatographic use which comprises an inorganic carrier having hydroxyl groups at the surface thereof having grafted thereon an alpha -arylalkylamine derivative which is formed by bonding an optically active alpha -arylalkylamine and an aminoalkylsilane through a dibasic carboxylic acid, and a method for liquid chromatographic analysis of an enantiomer mixture using this packing material as a stationary phase. The packing material of the present invention can be easily produced by the usual chemical reaction, is chemically stable, and exhibits excellent effects in the separation of an enantiomer mixture of a compound having an -NH- group, -CONH- group, or an -OCO- group bonded to an asymmetric carbon atom thereof.