STABLE PLURILAMELLAR VESICLES

摘要

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), as well as the process for making which comprises forming a dispersion of at least one amphipathic lipid, such as phosphatidyl choline, in an organic solvent, combining the dispersion with a sufficient amount of an aqueous phase to form a biphasic mixture in which the aqueous phase can be completely emulsified, and emulsifying the aqueous phase and evaporating the organic solvent of the biphasic mixture. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.