| 摘要 |
NEW MATERIAL:A compound shown by the formulaI[R1 is 1-6C alkyl, 2- 6C alkenyl containing 1-3 double bonds, R3-(CH2)a(R3 is 3-6C cycloalkyl, 3-6C cycloalkyl containing 1-2 double bonds, etc.; a is 0-3), R4-(CH2)b(R4 is amino, guanidino, etc.; b is 1-5), etc.]and its acid addition salt. EXAMPLE:4-Amidino-2-benzoylphenyl acetate. USE:An anticomplement agent. Useful as an antitrypsin agent, antiplasmin agent, antikallikrein agent, or antithrombin agent. PROCESS:A carboxylic acid compound shown by the formula R1-COOH or its reactive intermediate is reacted with an amidinophenol derivative shown by the formula II, preferably its acid addition salt, to give a compound shown by the formulaI. |
