发明名称 |
1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES |
摘要 |
(-)-Cis-4-amino-1- (2-hydroxymethyl-1,3 -oxathiolan-5-yl)-(1H)- pyrimidin-2-one (I) and its derivs. are new. (I) contg. max. 5 wt% of (+)-enantiomer (pref. below 1 wt%) is also claimed. (I) is prepd. by sepn. from a racemic mixt., preferably by chiral HPLC. The stationary phase used is preferably beta-cyclodextrin or cellulose triacetate. Alternatively sepn. is by enzyme-mediated enantioselective catabolism, preferably using an immobilised enzyme. The enzyme is preferably cytidine deaminase or a 5-nucleotidase. |
申请公布号 |
ZA9103293(B) |
申请公布日期 |
1992.02.26 |
申请号 |
ZA19910003293 |
申请日期 |
1991.04.30 |
申请人 |
IAF BIOCHEM INTERNATIONAL, INC. |
发明人 |
JONATHAN ALAN VICTOR COATES;IAN MARTIN MUTTON;CHARLES RICHARD PENN;RICHARD STORER;CHRISTOPHER WILLIAMSON |
分类号 |
C07D411/04;A61K31/00;A61K31/505;A61K31/506;A61K31/51;A61K31/513;A61K31/7072;A61K31/7076;A61K45/06;A61P31/00;A61P31/12;A61P31/18;A61P37/04;C07B57/00;C12P41/00 |
主分类号 |
C07D411/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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