NUCLEIC ACID COMPOUNDS FOR INHIBITING FOS GENE EXPRESSION AND USES THEREOF
摘要
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing FOS gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a FOS mRNA. In addition, the meroduplex may have at least one uridine is a 5-methyluridine, a nucleoside is a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a FOS gene in a cell or in a subject to treat a FOS-related disease.
申请公布号
WO2008109454(A2)
申请公布日期
2008.09.12
申请号
WO2008US55524
申请日期
2008.02.29
申请人
MDRNA, INC.;QUAY, STEVEN, C.;MCSWIGGEN, JAMES;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD
发明人
QUAY, STEVEN, C.;MCSWIGGEN, JAMES;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD