A disposable shoe cover (20) is provided for use with a wide range of foot sizes and different types of shoes and/or boots. A disposable shoe cover can be fabricated from a wide variety of different materials to enhance the performance of the resulting shoe cover. A disposable shoe cover is formed from three separate panels of material (41, 43, 45) seamed together or from a single continuous web of material segmented into three panels by elastomeric bands. In one embodiement, the shoe cover may also include an angled seam section along the back heel portion to prevent bunching of the sole portion at or under the sole of the shoe.