DERIVATIVES OF FORTIMICIN B AND PROCESS FOR PREPARING SAME

摘要

4,2'-di-N-Substitued derivatives of fortimicin B, represented by the formula: wherein R1 represents a -?-R, or -CH,-R, group, and R2 represents a or -CH2-R4 group and wherein R4 represents an aminoalkyl group having 1 to 8 carbon atoms, hydroxyalkyl group having 1 to 8 carbon atoms carbamoylaminoalkyl group having 2 to 9 carbon atoms or .omega.-aminohydroxyalkyl group having 2 to 9 carbon atoms wherein the amino group and hydroxy group are bonded to different carbon atoms, and R3 represent a carbamoylaminoalkyl group having 2 to 9 carbon atoms, and the pharmaceutically acceptable non-toxic acid addition salts thereof. The derivatives, which display good stability under strongly alkaline conditions and enhanced antibacterial activity, are prepared by chemically modifying fortimicin B.