发明名称 |
Transgenic mice expressing microRNA34 that have cells displaying increased senescence and apoptosis |
摘要 |
A transgenic, non-human animal model for accelerated aging and/or age-related symptom, recombinant nucleic acid molecules, cells and methods that can be used to make such animal model and cells, methods of using the animal model and cells, to descendants of the transgenic non-human animal, obtained by breeding with the same or with another phenotype, and to a cell line or primary cell culture or to an organotypic brain slice culture, derived from the transgenic non-human animal or its descendants are disclosed. |
申请公布号 |
US9402376(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201314371628 |
申请日期 |
2013.01.11 |
申请人 |
ADVANCED GENOMIC TECHNOLOGY, LLC |
发明人 |
Wang Eugenia |
分类号 |
A01K67/027;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
Baker & Hostetler LLP |
代理人 |
Baker & Hostetler LLP |
主权项 |
1. A transgenic mouse or progeny thereof, wherein the genome of the mouse or progeny thereof comprises a construct comprising a heterologous nucleic acid molecule encoding microRNA miR-34a or miR-34c operably linked to a promoter, said mouse or progeny thereof having cells that display increased senescence or apoptosis rate as compared to a wild-type mouse. |
地址 |
Louisville KY US |