| 摘要 |
A prosthetic graft is disclosed comprised of two coaxial prosthetic tubes confining a space that contains cells that are genetically engineered to overproduce a thrombolytic enzyme. The cells may comprise endothelial cells, smooth muscle cells, fibroblasts, and stem cells. The outer tube is a standard graft. The inner tube is a semipermeable membrane to protect the genetically engineered cells from the shear stress of blood flow and from exposure to inflammatory cells and platelets, while allowing free diffusion and exchange of the thrombolytic enzyme, essential nutrients from the circulation, and waste products of metabolism. |
