Use of the modified polysaccharides for heparin neutralization

摘要

The subject of the invention is the use of cationically modified polysaccharides, except for chitosan, for direct neutralization of heparin in blood and physiological fluids in a mammal. Cationic modification of the polysaccharides is achieved using compound containing cationic ammonium groups and/or the polysaccharides are grafted with a polymer containing amine and/or ammonium groups.

主权项

1. A method of direct neutralization of unfractionated heparin in blood and physiological fluids comprising intravenously administering to a mammal in need thereof cationically modified polysaccharides comprising hydroxypropyl cellulose grafted with N-acrylamidopropyl-N,N,N-trimethylammonium chloride.