发明名称 |
COMPOSITIONS AND METHODS FOR REGULATING CAR T CELLS |
摘要 |
The present invention provides compositions and methods for inhibiting the depletion of healthy tissue during CAR T cell therapy. In another embodiment, the invention includes a drug-molecule conjugate which is administered to a subject receiving CAR T cell therapy, where the conjugate binds to the CAR resulting in internalization of the conjugate and inhibition of T cell activity and/or death of the T cell. |
申请公布号 |
KR20150030724(A) |
申请公布日期 |
2015.03.20 |
申请号 |
KR20157000921 |
申请日期 |
2013.07.12 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
JUNE CARL H.;LEVINE BRUCE L.;KALOS MICHAEL D. |
分类号 |
A61K39/395;A61K47/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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