6-alkynyl-pyridine derivatives

摘要

6-Alkynyl-pyridine of general formula (I);
their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer. An exemplary compound is
;

主权项

1. A compound of formula I wherein R1 is selected from the group consisting of hydrogen, —C1-3alkyl and halogen; R2 is selected from the group consisting of hydrogen, —C1-3alkyl and halogen; R3 is selected from the group consisting of phenyl, R4 is a 5- or 6-membered heteroaryl substituted with —C1-3alkyl or —O—C1-3alkyl; or a pharmaceutically acceptable salt thereof.