| 摘要 |
Methods of treating diseases associated with P2X3 and/or a P2X2/ with compounds;;formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. |
| 主权项 |
1. A method for modulating P2X3 and R2X2/3 receptor activity in a subject comprising administering to a subject in need thereof an therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein: R1 is C1-6alkyl or halo; R2 is C3-6cycloalkyl, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl, or heteroaryl-C1-6alkyl; R3 is hydrogen, halo, C1-6alkyl, or C1-6alkoxy-carbonyl; R4 is hydrogen, halo, C1-6alkyl; or,
R3 and R4 together with the atoms to which they are attached may form a fused 6-membered aromatic ring that optionally includes one or two nitrogens; or, R3 and R4 together with the atom to which they are attached may form C3-6cycloalkyl; R5, R6 and R7 each independently is fluoro or hydrogen. X is CRa− wherein Ra is C1-6alkyl or halo; and, Y is —O—, —CHRb—, or —NRc—, wherein Rb and Rc each independently is hydrogen or C1-6alkyl;with the proviso that when Y is CH2, R2 is C3-6cycloalkyl, C1-6alkoxy-C1-6alkyl, or hydroxy-C1-6alkyl. |
