发明名称 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS
摘要 The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
申请公布号 WO2016086200(A1) 申请公布日期 2016.06.02
申请号 WO2015US62794 申请日期 2015.11.25
申请人 GENENTECH, INC.;CONSTELLATION PHARMACEUTICALS, INC. 发明人 ROMERO, F. ANTHONY;MAGNUSON, STEVEN;PASTOR, RICHARD;TSUI, VICKIE HSIAO-WEI;MURRAY, JEREMY;CRAWFORD, TERRY;ALBRECHT, BRIAN, K.;COTE, ALEXANDRE;TAYLOR, ALEXANDER, M.;LAI, KWONG WAH;CHEN, KEVIN, X.;BRONNER, SARAH;ADLER, MARC;EGEN, JACKSON;LIAO, JIANGPENG;WANG, FEI;CYR, PATRICK;ZHU, BING-YAN;KAUDER, STEVEN
分类号 C07D471/04;A61K31/437;A61P29/00;A61P35/00;A61P37/00 主分类号 C07D471/04
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