发明名称 |
TENOCYTE CONTAINING BIOSCAFFOLDS AND TREATMENT USING THE SAME |
摘要 |
The present invention relates to methods for preparing bioscaffolds useful in the repair of tears. More specifically, the invention relates to a method of treating rotator cuff tear in a mammalian subject in need thereof comprising the steps of: (i) selectively expanding tenocytes in vitro in culture medium comprising insulin or a functional derivative and a glucocorticoid or a glucocorticoid-like molecule to produce a culture of expanded tenocytes; (ii) seeding a bioscaffold with said expanded tenocytes to produce a tenocyte seeded bioscaffold; and (iii) implanting said tenocyte seeded bioscaffold proximal to the rotator cuff tear. The present invention also relates to a bioscaffold comprising cells, wherein more than 80 % of said cells are tenocytes. |
申请公布号 |
CA2685146(C) |
申请公布日期 |
2016.03.29 |
申请号 |
CA20082685146 |
申请日期 |
2008.04.24 |
申请人 |
THE UNIVERSITY OF WESTERN AUSTRALIA |
发明人 |
ZHENG, MING-HAO |
分类号 |
A61L27/00;A61F2/02;A61F2/08;A61F2/30;A61L27/18;A61L27/36;A61L27/38 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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