MODIFIED T LYMPHOCYTES HAVING IMPROVED SPECIFICITY

摘要

Provided herein are modified T lymphocytes comprising chimeric receptors and methods of use thereof.

主权项

1. A modified T lymphocyte comprising:
a. a first polypeptide comprising a first extracellular antigen binding domain that binds a first antigen, and a first intracellular signaling domain, wherein said first polypeptide does not comprise a co-stimulatory domain; and b. a second polypeptide comprising a second extracellular antigen binding domain binding a second antigen, or a receptor that binds said second antigen; and a second intracellular signaling domain; wherein said modified lymphocyte becomes maximally cytotoxic only when said first signaling domain and said second signaling domain are both activated by said first antigen and said second antigen, respectively.