| 发明名称 |
Dermal filler |
| 摘要 |
Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin. |
| 申请公布号 |
US9161970(B2) |
申请公布日期 |
2015.10.20 |
| 申请号 |
US200711954602 |
申请日期 |
2007.12.12 |
| 申请人 |
Allergan, Inc. |
发明人 |
Tezel Ahmet;Blanda Wendy M.;Hughes Patrick M.;Whitcup Scott M.;Chang James N.;Robinson Michael R. |
| 分类号 |
A61K47/36;A61K47/12;A61K47/10;A61L27/10;A61L27/54;A61L27/20;A61K38/48;A61K9/00 |
主分类号 |
A61K47/36 |
| 代理机构 |
|
代理人 |
Phan Brigitte C.;Chan Ted A.;Condino Debra D. |
| 主权项 |
1. A method for treating a facial wrinkle by administering to the patient a pharmaceutical composition comprising
a) a botulinum neurotoxin, b) a serum albumin, wherein the concentration of the serum albumin in the pharmaceutical composition is about 5 μg or less per unit of the botulinum neurotoxin, and c) a viscous carrier comprising a cross-linked hyaluronic acid, wherein said cross-linked hyaluronic acid has a cross-linking density of from 5% to about 10%,wherein the patient's facial wrinkles are alleviated for a longer period of time than they are by administration of a pharmaceutical composition which does not comprise a botulinum neurotoxin. |
| 地址 |
Irvine CA US |
