发明名称 |
BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPHY |
摘要 |
<p>Bispecific binding molecules, in particular immunoglobulin single variable domains such as VHHs and domain antibodies, comprising a VEGF-binding component and a DII4-binding component in one molecule. Pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with VEGF- and DII4-mediated effects on angiogenesis. Nucleic acids encoding the bispecific binding molecules, host cells and methods for preparing same.</p> |
申请公布号 |
IN2752DEN2012(A) |
申请公布日期 |
2015.09.18 |
申请号 |
IN2012DELNP2752 |
申请日期 |
2012.03.30 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
ERIC BORGES;ANDREAS GSCHWIND;JOACHIM BOUCNEAD;EVELYN DE TAVERNIER;JOOST KOLKMAN;PASCAL MERCHIERS;DAINE VAN HOORICK |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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