APPARATUS AND METHODS FOR NON-INVASIVE ASSESSMENT OF TRANSPLANT KIDNEY VIABILITY

摘要

A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire surface of kidney, and the image processing algorithm automatically segments and quantifies the diameter and/or density of the kidney microstructures, blood flows, etc., and quantitative values are displayed in real-time on a display of the KVAS.

主权项

1. A system for non-invasive assessment of a transplant or donor kidney, said system comprising:
an optical device for imaging the donor kidney in vivo and generating at least one image; and at least one processor configured for receiving the at least one image from the optical device, and further configured for executing a set of instructions corresponding to an algorithm for processing the at least one image and determining at least one characteristic corresponding to the viability of the donor kidney.