植物萃取物及治疗肝脏纤维化与肝癌之方法;PLANT EXTRACT AND THE PROCESS FOR TREATING HEPATIC FIBROSIS AND LIVER CANCER

摘要

本发明系关于一种藉由包括以下之方法制备的石莲花(Graptopetalum paraguayense)萃取物：用酒精溶剂萃取石莲花(GP)起始物质，产生酒精萃取物及残余物；使该残余物与该酒精萃取物分离；用二申亚碸(DMSO)水溶液溶剂萃取该残余物，产生DMSO萃取物；该DMSO萃取物使用具有选定分子量截断值之过滤器进行超过滤；乾燥由该过滤器截留的级分，获得该石莲花萃取物。本发明系关于石莲花萃取物之用途，其用于治疗或预防肝纤维化、肝脏硬化、肝癌、术后肝纤维化复发或术后肝癌复发。; separating the residue from the alcoholic extract; extracting the residue with an aqueous dimethyl sulfoxide (DMSO) solvent to produce a DMSO extract; subjecting the DMSO extract to ultrafiltration using a filter having a selected molecular weight cutoff; drying a fraction retained by the filter to obtain the extract ofGraptopetalum paraguayense. Uses of an extract ofGraptopetalum paraguayensefor the treatment or prevention of liver fibrosis, hepatic cirrhosis, liver cancer, recurrence of liver fibrosis after surgery, or recurrence of liver cancer after surgery.