| 发明名称 |
Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain |
| 摘要 |
The present invention relates to the use of a compound of Formula (I′″) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of arthritis and pain. |
| 申请公布号 |
US9060966(B2) |
申请公布日期 |
2015.06.23 |
| 申请号 |
US200712377837 |
申请日期 |
2007.08.15 |
| 申请人 |
|
发明人 |
Cuevas Sánchez Pedro;Gimenez Gallego Guillermo;Saenz de Tejada Morgan Inigo;Angulo Frutos Javier;Lozano Puerto Rosa Maria;Romero Garrido Antonio;Valverde Lopez Serafin |
| 分类号 |
A61K31/045;A61K31/15;A61K31/10;A61K31/192;A61K31/60;A61K31/618 |
主分类号 |
A61K31/045 |
| 代理机构 |
Frommer Lawrence & Haug LLP |
代理人 |
Frommer Lawrence & Haug LLP |
| 主权项 |
1. A method of treating arthritis and pain, wherein the arthritis is osteoarthritis and the pain is inflammatory pain, comprising administering to an individual in need thereof a pharmaceutically effective amount of a compound of Formula (I′″) or pharmaceutically acceptable salt thereof, wherein the compound of Formula (I′″) is:wherein:
R1 is —(CH2)a Y; Y is —SO3H, R9 and R9′ are independently selected from —OH and —OR2, wherein at least one of R9 and R9′ is an unsubstituted alkylcarbonyloxy group, and wherein when R9 and R9′ are both —OR2, then said R9 and R9′ can be the same or different; R2 is an unsubstituted alkylcarbonyl group; and a is a number selected from 0, 1. |
| 地址 |
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