| 发明名称 | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) | ||
| 摘要 | A cell culture media for growing transformant pGDF-5-Trc-transformed cells is provided for increased production of transformant pGDF-5-Trc-transformed cells. Also provided herein are methods of growing the transformant pGDF-5-Trc-transformed cells. The methods of growing the transformant pGDF-5-Trc-transformed cells as disclosed are cost-effective, time-saving and are of manufacturing quality. | ||
| 申请公布号 | US9051389(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US201313750765 | 申请日期 | 2013.01.25 |
| 申请人 | Warsaw Orthopedic, Inc. | 发明人 | Harrington Roger E.;Scher David S. |
| 分类号 | C12P21/04;C07K14/495 | 主分类号 | C12P21/04 |
| 代理机构 | Sorell Lenna & Schmidt LLP | 代理人 | Sorell Lenna & Schmidt LLP |
| 主权项 | 1. A cell culture media for growing transformant pGDF-5-Trc-transformed cells, the cell culture media comprising a transformant pGDF-5-Trc-transformed cells, wherein the pH of the cell culture media is from about 6.8 to about 7, and the GDF-5-Trc-transformed cells comprise a polynucleotide sequence that encodes the amino acid sequence of SEQ ID NO: 4. | ||
| 地址 | Warsaw IN US | ||