| 发明名称 | Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor | ||
| 摘要 | Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. | ||
| 申请公布号 | US8962330(B2) | 申请公布日期 | 2015.02.24 |
| 申请号 | US200711981022 | 申请日期 | 2007.10.31 |
| 申请人 | The Trustees of the University of Pennsylvania | 发明人 | Gao Guangping;Wilson James M.;Alvira Mauricio R. |
| 分类号 | C12N15/63;C12N15/85;A61K35/76;C07K14/005;C07K14/755;C12N7/00;C12N15/86;A61K48/00 | 主分类号 | C12N15/63 |
| 代理机构 | Howson & Howson LLP | 代理人 | Howson & Howson LLP |
| 主权项 | 1. An adeno-associated virus (AAV) 8 viral vector comprising an AAV8 capsid having packaged therein a heterologous gene operably linked to regulatory sequences which direct its expression, wherein the heterologous gene encodes a low density lipoprotein receptor (LDLr), wherein the AAV8 capsid comprises a vp3 capsid protein having the sequence of aa 203 to 737 of SEQ ID NO:2, or a sequence which is at least 95% identical to said sequence of aa 203 to 737 of SEQ ID NO:2. | ||
| 地址 | Philadelphia PA US | ||