AZABICYCLO COMPOUND AND SALT THEREOF

摘要

IT IS INTENDED TO PROVIDE A NOVEL AZABICYCLO COMPOUND WHICH EXHIBITS BOTH HSP90 INHIBITORY ACTIVITY AND CELL PROLIFERATION INHIBITORY EFFECT. SPECIFICALLY DISCLOSED IS A COMPOUND REPRESENTED BY THE FOLLOWING GENERAL FORMULA (I) OR A SALT THEREOF: WHEREIN X1 REPRESENTS CH OR N; ANY ONE OF X2, X3 AND X4 REPRESENTS N, AND THE OTHERS REPRESENT CH; ANY ONE OR TWO OF Y1, Y2, Y3 AND Y4 REPRESENT C-R4, AND THE OTHERS ARE THE SAME OR DIFFERENT AND REPRESENT CH OR N; R1 REPRESENTS ON OPTIONALLY SUBSTITUTED MONOCYCLIC OR BICYCLIC UNSATURATED HETEROCYCLIC GROUP HAVING 1 TO 4 HETEROATOMS SELECTED FROM N, S AND O; R2 REPRESENTS AN ALKYL GROUP HAVING 1 TO 6 CARBON ATOMS, OR THE LIKE; AND R3 AND R4 REPRESENT ?CO-R5 OR THE LIKE.