ALZHEIMER'S DISEASE SIGNATURE MARKERS AND METHODS OF USE

摘要

Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimer's disease (AD). In one embodiment, BioAge (biological age), NdStress (neurodegenerative stress), Alz (Alzheimer), and Inflame (inflammation) are used as biomarkers of AD progression. In another aspect, the invention comprises a gene signature for evaluating disease progression. In still another embodiment, methods for evaluating disease progression are provided. In yet another embodiment, the invention can be used to identify animal models for use in the development and evaluation of therapeutics for the treatment of AD.

主权项

1. A biomarker comprising a set of one or more correlated genes, having a gene signature score that is significantly different between groups of tissue samples according to a statistical test, wherein the signature score is equivalent to the average gene expression of the up-regulated genes for said marker minus the average gene expression of the down-regulated genes.