发明名称 |
MICRONEEDLE DEVICE HAVING A PEPTIDE THERAPEUTIC AGENT AND AN AMINO ACID, METHODS OF MAKING AND USING THE SAME |
摘要 |
<p>A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.</p> |
申请公布号 |
EP2785327(A1) |
申请公布日期 |
2014.10.08 |
申请号 |
EP20120799452 |
申请日期 |
2012.11.30 |
申请人 |
3M INNOVATIVE PROPERTIES COMPANY |
发明人 |
ZHANG, YING;FENN,PERCY T.;JOHNSON, PETER R. |
分类号 |
A61K9/00;A61K31/4172;A61K47/16;A61M37/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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